In modern times, however, the vampire is generally held to be a fictitious entity, although belief in similar vampiric creatures such as the chupacabra still persists in some cultures. Early folkloric belief in Vampires has been ascribed to the ignorance of the body's process of decomposition after death and how people in pre-industrial societies tried to rationalise this, creating the figure of the vampire to explain the mysteries of death. Porphyria was also linked with legends of vampirism in 1985 and received much media exposure, but has since been largely discredited.

The charismatic and sophisticated vampire of modern fiction was born in 1819 with the publication of The Vampyre by John Polidori; the story was highly successful and arguably the most influential vampire work of the early 19th century. However, it is Bram Stoker's 1897 novel Dracula which is remembered as the quintessential vampire novel and provided the basis of the modern vampire legend. The success of this book spawned a distinctive vampire genre, still popular in the 21st century, with books, films, and television shows. The vampire has since become a dominant figure in the horror genre.

The notion of vampirism has existed for millennia; cultures such as the Mesopotamians, Hebrews, Ancient Greeks, and Romans had tales of demons and spirits which are considered precursors to modern Vampires. However, despite the occurrence of vampire-like creatures in these ancient civilizations, the folklore for the entity we know today as the vampire originates almost exclusively from early 18th century Southeastern Europe, when verbal traditions of many ethnic groups of the region were recorded and published. In most cases, Vampires are revenants of evil beings, suicide victims, or witches, but they can also be created by a malevolent spirit possessing a corpse or by being bitten by a vampire. Belief in such legends became so pervasive that in some areas it caused mass hysteria and even public executions of people believed to be Vampires.

It is difficult to make a single, definitive description of the folkloric vampire, though there are several elements common to many European legends. Vampires were usually reported as bloated in appearance, and ruddy, purplish, or dark in colour; these characteristics were often attributed to the recent drinking of blood. Indeed, blood was often seen seeping from the mouth and nose when one was seen in its shroud or coffin and its left eye was often open. It would be clad in the linen shroud it was buried in, and its teeth, hair, and nails may have grown somewhat, though in general fangs were not a feature.

Other attributes varied greatly from culture to culture; some Vampires, such as those found in Transylvanian tales, were gaunt, pale, and had long fingernails, while those from Bulgaria only had one nostril, and Bavarian Vampires slept with thumbs crossed and one eye open. Moravian Vampires only attacked while naked, and those of Albanian folklore wore high-heeled shoes. As stories of Vampires spread throughout the globe to the Americas and elsewhere, so did the varied and sometimes bizarre descriptions of them: Mexican Vampires had a bare skull instead of a head, Brazilian Vampires had furry feet and Vampires from the Rocky Mountains only sucked blood with their noses and from the victim's ears. Common attributes were sometimes described, such as red hair. Some were reported to be able to transform into bats, rats, dogs, wolves, spiders and even moths. From these various legends, works of literature such as Bram Stoker's Dracula, and the influences of historical bloodthirsty figures such as Gilles de Rais, Elizabeth Bathory, and Vlad Ţepeş, the vampire developed into the modern stereotype.

The causes of vampiric generation were many and varied in original folklore. In Slavic and Chinese traditions, any corpse which was jumped over by an animal, particularly a dog or a cat, was feared to become one of the undead. A body with a wound which had not been treated with boiling water was also at risk. In Russian folklore, Vampires were said to have once been witches or people who had rebelled against the Church while they were alive.

Cultural practices often arose that were intended to prevent a recently deceased loved one from turning into an undead revenant. Burying a corpse upside-down was widespread, as was placing earthly objects, such as scythes or sickles, near the grave to satisfy any demons entering the body or to appease the dead so that it would not wish to arise from its coffin. This method resembles the Ancient Greek practice of placing an obolus in the corpse's mouth to pay the toll to cross the River Styx in the underworld; it has been argued that instead, the coin was intended to ward off any evil spirits from entering the body, and this may have influenced later vampire folklore. This tradition persisted in modern Greek folklore about the vrykolakas, in which a wax cross and piece of pottery with the inscription "Jesus Christ conquers" were placed on the corpse to prevent the body from becoming a vampire. Other methods commonly practised in Europe included severing the tendons at the knees or placing poppy seeds, millet, or sand on the ground at the grave site of a presumed vampire; this was intended to keep the vampire occupied all night by counting the fallen grains. Similar Chinese narratives state that if a vampire-like being came across a sack of rice, it would have to count every grain; this is a theme encountered in myths from the Indian subcontinent as well as in South American tales of witches and other sorts of evil or mischievous spirits or beings.

Many elaborate rituals were used to identify a vampire. One method of finding a vampire's grave involved leading a virgin boy through a graveyard or church grounds on a virgin stallion — the horse would supposedly balk at the grave in question. Generally a black horse was required, though in Albania it should be white. Holes appearing in the earth over a grave were taken as a sign of vampirism.

Corpses thought to be Vampires were generally described as having a healthier appearance than expected, plump and showing little or no signs of decomposition. In some cases, when suspected graves were opened, villagers even described the corpse as having fresh blood from a victim all over its face. Evidence that a vampire was active in a given locality included death of cattle, sheep, relatives or neighbours. Folkloric Vampires could also make their presence felt by engaging in minor poltergeist-like activity, such as hurling stones on roofs or moving household objects, and pressing on people in their sleep.

In modern fiction, the vampire tends to be depicted as a suave, charismatic villain. Despite the general disbelief in vampiric entities, occasional sightings of Vampires are reported. Indeed, vampire hunting societies still exist, although they are largely formed for social reasons. Allegations of vampire attacks swept through the African country of Malawi during late 2002 and early 2003, with mobs stoning one individual to death and attacking at least four others, including Governor Eric Chiwaya, based on the belief that the government was colluding with Vampires.

In early 1970 local press spread rumors that a vampire haunted Highgate Cemetery in London. Amateur vampire hunters flocked in large numbers to the cemetery. Several books have been written about the case, notably by Sean Manchester, a local man who was among the first to suggest the existence of the "Highgate Vampire" and who later claimed to have exorcised and destroyed a whole nest of Vampires in the area. In January 2005, rumours circulated that an attacker had bitten a number of people in Birmingham, England, fuelling concerns about a vampire roaming the streets. However, local police stated that no such crime had been reported and that the case appears to be an urban legend.

In one of the more notable cases of vampiric entities in the modern age, the chupacabra ("goat-sucker") of Puerto Rico and Mexico is said to be a creature that feeds upon the flesh or drinks the blood of domesticated animals, leading some to consider it a kind of vampire. The "chupacabra hysteria" was frequently associated with deep economic and political crises, particularly during the mid-1990s.

In Europe, where much of the vampire folklore originates, the vampire is considered a fictitious being, although many communities have embraced the revenant for economic purposes. In some cases, especially in small localities, vampire superstition is still rampant and sightings or claims of vampire attacks occur frequently. In Romania during February 2004, several relatives of Toma Petre feared that he had become a vampire. They dug up his corpse, tore out his heart, burned it, and mixed the ashes with water in order to drink it.

Vampirism also represents a relevant part of modern day's occultist movements. The mythos of the vampire, his magickal qualities, allure, and predatory archetype express a strong symbolism that can be used in ritual, energy work, and magick, and can even be adopted as a spiritual system. The vampire has been part of the occult society in Europe for centuries and has spread into the American sub-culture as well for more than a decade, being strongly influenced by and mixed with the neo gothic aesthetics.

Considered one of the preeminent figures of the classic horror film, the vampire has proven to be a rich subject for the film and gaming industries. Dracula is a major character in more movies than any other but Sherlock Holmes, and many early films were either based on the novel of Dracula or closely derived from it. These included the landmark 1922 German silent film Nosferatu, directed by F. W. Murnau and featuring the first film portrayal of Dracula—although names and characters were intended to mimic Dracula's, Murnau could not obtain permission to do so from Stoker's widow, and had to alter many aspects of the film. In addition to this film was Universal's Dracula (1931), starring Béla Lugosi as the count in what was the first talking film to portray Dracula. The decade saw several more vampire films, most notably Dracula's Daughter in 1936.

The legend of the vampire was cemented in the film industry when Dracula was reincarnated for a new generation with the celebrated Hammer Horror series of films, starring Christopher Lee as the Count. The successful 1958 Dracula starring Lee was followed by seven sequels. Lee returned as Dracula in all but two of these and became well known in the role. By the 1970s, Vampires in films had diversified with works such as Count Yorga, Vampire (1970), an African Count in 1972's Blacula, a Nosferatu-like vampire in 1979's Salem's Lot, and a remake of Nosferatu itself, titled Nosferatu the Vampyre with Klaus Kinski the same year. Several films featured female, often lesbian, vampire antagonists such as Hammer Horror's The Vampire Lovers (1970) based on Carmilla, though the plotlines still revolved around a central evil vampire character.

The pilot for the Dan Curtis 1974 television series Kolchak: The Night Stalker revolved around reporter Carl Kolchak hunting a female vampire in the greater Los Angeles area. Later films showed more diversity in plotline, with some focusing on the vampire-hunter such as Blade in the Marvel Comics' Blade films and the film Buffy the Vampire Slayer. Buffy, released in 1992, foreshadowed a vampiric presence on television, with adaptation to a long-running hit TV series of the same name and its spin-off Angel. Still others showed the vampire as protagonist such as 1983's The Hunger, 1994's Interview with the Vampire: The Vampire Chronicles and its indirect sequel of sorts Queen of the Damned. Bram Stoker's Dracula was a noteworthy 1992 remake which became the then-highest grossing vampire film ever. This increase of interest in vampiric plotlines led to the vampire being depicted in movies such as Underworld and Van Helsing, the Russian Night Watch and a TV miniseries remake of 'Salem's Lot, both from 2004. The continuing popularity of the vampire theme has been ascribed to a combination of two factors: the representation of sexuality — something which has become more overt in the Internet age — and the perennial dread of mortality.